By Annarosa Leri MD, Piero Anversa MD, William H. Frishman MD

ISBN-10: 0470994304

ISBN-13: 9780470994306

ISBN-10: 140514842X

ISBN-13: 9781405148429

This publication is the definitive reference on of the main fascinating parts of cardiovascular learn – myocardial regeneration and stem telephone remedy – for the therapy of sickness. Edited through pioneers within the zone, with contributions from each significant investigator world wide, it covers:

  • The biology of stem cells
  • The activities of stem cells from the bone marrow, the center, and embryos at the common restorative and service features of the guts and blood vessels
  • How stem cells may give a contribution to myocardial restoration within the face of harm and getting older
  • How adjuvant treatment with development elements may possibly increase stem mobile job in regeneration and service
  • Clinical purposes and scientific experiences

This totally referenced ebook offers the present nation of data in either easy technology and medical perform, and is an important reference for scientists, scholars, and clinicians.

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Extra info for Cardiovascular Regeneration and Stem Cell Therapy

Sample text

We confirmed these results [88], while Cheshire and colleagues [82], using a different mouse strain and stem cell separation, but the same basic model, also confirmed the Bradford results, but with more rapid kinetics. Thus, stem cells are a cycling cell population. This is important for our understanding of the significance of studies, which we will describe below, showing that LRH cells demonstrate reversible changes in phenotype with cycle transit. We have established that murine marrow stem cells show marked changes in short- and long-term engraftment as they march through a cytokine stimulated cell cycle [89, 90].

Cell 2002; 111(4):589–601. Bittner RE, Schofer C, Weipoltshammer K, et al. Recruitment of bone-marrow-derived cells by skeletal and cardiac muscle in adult dystrophic mdx mice. Anat Embryol (Berl) 1999; 199(5):391–396. Gussoni E, Soneoka Y, Strickland CD, et al. Dystrophin expression in the mdx mouse restored by stem cell transplantation. Nature 1999; 401(6751):390–394. Abedi M, Greer DA, Colvin GA, et al. Tissue injury in marrow transdifferentiation. Blood Cells Mol Dis 2004; 32(1):42–46. Abedi M, Greer DA, Colvin GA, et al.

Murry CE, Soonpaa MH, Reinecke H, et al. Haematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infarcts. Nature 2004; 428(6983):664–668. Jackson KA, Majka SM, Wang H, et al. Regeneration of ischemic cardiac muscle and vascular endothelium by adult stem cells. J Clin Invest 2001; 107(11):1395– 1402. Kocher AA, Schuster MD, Szabolcs MJ, et al. Neovascularization of ischemic myocardium by human bone-marrow-derived angioblasts prevents cardiomyocyte apoptosis, reduces remodeling, and improves cardiac function.

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Cardiovascular Regeneration and Stem Cell Therapy by Annarosa Leri MD, Piero Anversa MD, William H. Frishman MD


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