By Rolf Bodmer (Eds.)

ISBN-10: 0444530142

ISBN-13: 9780444530141

In 1993, Rolf Bodmer defined a gene he named tinman that was once required for the formation of the dorsal aorta of the fly. Flies with no sensible tinman gene had no middle. speedy, mammalian opposite numbers of the tinman gene have been pointed out and located to be expressed through early cardiomyogenic precursors and through cardiomyocytes all through center improvement. in view that then, major development has been made within the realizing of molecular and genetic determinants of center formation. An ever starting to be variety of genes were pointed out which are required for cardiogenesis, as evidenced through serious abnormalities in cardiac improvement produced by way of inactivation within the mouse or inhibition of gene functionality in different version organisms. Cardiovascular improvement covers a number of the newest examine within the examine of center formation. quantity Editor Rolf Bodmer has assembled a world-class record of participants whose study makes use of various animal versions and whose findings are absolute to increase our knowing of this interesting box. * Ties jointly the improvement of center morphology and conduction procedure * the most recent advancements in vertebrate and invertebrate genetic version structures * Technological developments in cardiovascular technology

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15, 1502–1508. 26 Li Qian et al. , Frasch, M. 2000. Wingless effects mesoderm patterning and ectoderm segmentation events via induction of its downstream target sloppy paired. Development 24, 5497–5508. , Izumo, S. 1998. 5 physically associates with the zinc finger protein GATA4 and cooperatively activates atrial natriuretic factor gene expression. Mol. Cell Biol. 6, 3120–3129. Leptin, M. 1991. Twist and snail as positive and negative regulators during Drosophila mesoderm development. Genes Dev.

2005. Embryonic even skipped-dependent muscle and heart cell fates are required for normal adult activity, heart function, and lifespan. Circ. Res. 11, 1108–1114. A. 2000. Genetically distinct cardial cells within the Drosophila heart. Genesis 1, 36–43. A. 1999. The zinc finger proteins Pannier and GATA4 function as cardiogenic factors in Drosophila. Development 24, 5679–5688. , et al. 2003. GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5. Nature 424, 443–447.

Bodmer, R. 2002. The patterns of wingless, decapentaplegic, and tinman position the Drosophila heart. Mech. Dev. 1–2, 13–26. M. 2002. The Hox gene abdominal-A specifies heart cell fate in the Drosophila dorsal vessel. Development 21, 5019–5027. M. 2006. Activated FOXO-mediated insulin resistance is blocked by reduction of TOR activity. Cell Metab. 2, 133–142. R. 2006. Slit coordinates cardiac morphogenesis in Drosophila. Dev. Biol. 1, 154–164. , Krumlauf, R. 1992. Homeobox genes and axial patterning.

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Cardiovascular Development by Rolf Bodmer (Eds.)


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