By Marcus Flather, Deepak Bhatt, Tobias Geisler

ISBN-10: 1405162155

ISBN-13: 9781405162159

The velocity of healing advances within the remedy of cardiovascular illnesses is quick, and new clinically-relevant info appears to be like with such frequency that it may be super not easy for clinicians to maintain up.

Still, wisdom and interpretation of significant medical trials is important for the diversity of clinicians who deal with cardiovascular sufferers, particularly because very important trial proof usually should be applied quickly after it truly is published.

Confidently practice most advantageous remedy for 10 of the main serious components of cardiology
Written by way of a global group of specialists, Cardiovascular scientific Trials: placing the facts into Practice:

  • Provides a succinct review of contemporary significant scientific trials - the most excellent for all scientific remedy - throughout all of the significant cardiovascular subspecialties, to make sure you’re up to date at the most important findings
  • Guides cardiology trainees and clinicians on how cardiovascular medical trials are designed and carried out, together with statistical technique, so that you can behavior and/or appraise destiny trials yourself
  • Addresses method in addition to scientific effectiveness
  • Offers evidence-based exams at the optimum remedies and authoritative medical info on administration of the stipulations so that you can with a bit of luck follow what you learn

Physicians, surgeons, professional nurses – any clinician looking an obtainable source for designing and accomplishing cardiovascular trials after which translating their effects into perform will take pleasure in this book’s transparent counsel and succinct and functional approach.

  

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Extra resources for Cardiovascular Clinical Trials: Putting the Evidence into Practice

Example text

When a therapeutic treatment that has been shown to be efficacious in superiority trial(s) exists for treatment of serious illnesses, a placebo-controlled trial may be considered unethical. In that case, the scientifically sound use of an active treatment as a control should be considered. The appropriateness of placebo control versus active control should be considered on a trial-by-trial basis. Trials to show equivalence or non-inferiority This type of trial design might be the preferred strategy of the sponsor when there is the suspicion that an experimental treatment is not superior in terms of efficacy but may offer safety or compliance advantages compared to the active control [38].

For non-normally distributed data there are equivalent tests called nonparametric test; they are the Wilcoxon Rank Sum and Mann–Whitney tests. The above discussion may give the impression that for categorical and continuous data, rigid selection of Chi-square test, t-tests, Mann–Whitney or Wilcoxon tests is imperative. This is not the case and there is a substantial literature showing that, for example, the t-test is valid (robust) when used on simple five-point scale data. Here the five points may measure, for example, pain ranging from no pain (score 1) to maximum pain (score 5) [52–57].

All trial subjects (including those with censored follow-up) can provide important information for event analysis, and should therefore not be excluded from the analysis. However, considering the censoring time as an equivalent survival time might lead to biased estimate of survival time and event probability. Therefore, specific statistical methods to handle survival data need to be applied. In Introduction to randomized clinical trials in cardiovascular disease 29 clinical practice, all the subjects are not enrolled at the same time and thus the follow-up period can vary from one subject to another.

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Cardiovascular Clinical Trials: Putting the Evidence into Practice by Marcus Flather, Deepak Bhatt, Tobias Geisler


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