By Michael K. Pugsley

ISBN-10: 1588290972

ISBN-13: 9781588290977

ISBN-10: 1592594042

ISBN-13: 9781592594047

Cardiac Drug improvement consultant outlines, intimately, the therapeutics of cardiac drugs at present on the leading edge of medical study and improvement world wide. This quantity integrates easy and scientific cardiac pharmacology through c- bining, for the 1st time, either classical and molecular facets of healing drug improvement. The chapters include a wide spectrum of healing components and accordingly contain a finished dialogue of molecular, biochemical, and electrophy- ological strategies according to years of in vitro in addition to in vivo pharmacological st- ies. additionally, the latter a part of the e-book comprises accomplished medical cardiac chapters that describe vital themes in molecular drugs. those chapters additionally talk about present medical healing developments in medication and supply an assessment of the efficacy of novel medications in those components. Cardiac Drug improvement advisor has many designated and impressive beneficial properties that set it except different cardiac pharmacology books. This ebook introduces subject matters in an simply comprehensible structure for researchers in lots of various disciplines by means of integrating and thereby simplifying innovations now not frequently mentioned throughout a wide diversity of cardiac disciplines and in a hugely technical box. each one bankruptcy not just introduces and describes the body structure, pharmacology, and pathophysiology of the illness, but in addition overviews the medical implications of drug improvement, what levels those parts are at the moment in, and likewise stories many of the methodologies fascinated by drug discovery and improvement. hence, this e-book presents a finished evaluation of the main complex techniques in cardiac pharmacology this day.

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Additional info for Cardiac Drug Development Guide (Methods in Pharmacology and Toxicology)

Example text

C. Y. (2000) Measurement of body venous tone. J. Pharmacol. Toxicol. Meth. 44, 341–360. 48. Winslow, E. (1984) Methods in the detection and assessment of antiarrhythmic activity. Pharmacol. Ther. 24, 401–433. 49. Beatch, G. N. and Barrett, T. D. (1998) Monophasic action potential recording, in Methods in Cardiac Electrophysiology (Walker, M. J. , and Pugsley, M. ), CRC Press, Boca Raton, FL, pp. 117–132. 50. Cheung, P. , Pugsley, M. , and Walker, M. A. (1993) Arrhythmia models in the rat. J. Pharmacol.

REFERENCES 1. DiFrancesco, D. (1995) The onset and autonomic regulation of cardiac pacemaker activity: Relevance of the f current. Cardiovasc Res. 29, 449–456. 2. Yanagihara, K. and Irisawa, H. (1980) Inward current activated during hyperpolarization in the rabbit sinoatrial node cell. Pflugers Arch. 385, 11–19. 3. Brown, H. , and Noble, S. J. (1977) Membrane currents underlying activity in frog sinus venosus. J. Physiol. 271, 783–816. 4. DiFrancesco, D. (1981) A new interpretation of the pace-maker current in calf Purkinje fibres.

ZD 7288 is more selective than alinidine or UL-FS 49, producing less prolongation of the action potential in SAN cells at bradycardic concentrations (96). As noted previously, HCN channels are widely expressed in CNS and some peripheral tissues, and one could expect that blockers of HCN channels will have effects in these tissues as well as in the heart. In this context, most interest in ZD 7288 at present seems to be centered on its actions in neurons (97,98). ZD 7288 inhibits I(h) in rod photoreceptors (99), a finding that has relevance to one of the side effects of HCN channel blockers, which is that they produce visual disturbances.

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Cardiac Drug Development Guide (Methods in Pharmacology and Toxicology) by Michael K. Pugsley


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