By T. Khan

ISBN-10: 9535105779

ISBN-13: 9789535105770

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Example text

If we decide to approximate clinical measurements by a normal curve, we are deciding to use a parametric hyphotesis test. A hypothesis test asks if an effect (difference) exists or not using statistics tests to verify the hypothesis that there is no difference. This is the null hypothesis and designated H0. The hypothesis that contradicts H0 is the alternative hypothesis and written HA. In the null hypothesis we use the words no difference or equal to and in the alternative hypothesis we use the words different from, less than or greater than.

It may be observed in the interphases nucleus four signals characterizing normal cells (yellow arrows) and others interphases nucleus showing two signals (white arrows), confirming the loss of the chromosome 7. The molecular mechanisms involved in MDS mainly, in childhood, are not well defined. A recent molecular study of TP53 and c-fms genes showed no mutations in children with MDS. The presence of mutations in onocogene N-ras also occurs in a very low frequency in childhood MDS. , 2004, 2006).

Thus, being able to use these techniques needs some skills in order to choose the correct statistical test. 2 Parametric and nonparametric tests Combining the notion of a frequency distribution (descriptive statistics) and probability, we can explain what means a probability distribution. A probability distribution is a table or a graph that describes the probability of an event occurs. It describes what probably will happen instead of describing what really happened. A probability distribution can be discrete or continuous.

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Biomarker by T. Khan


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